The first outpost
of Czech science
in the United States.

Tenofovir disoproxil fumarate — a cornerstone HIV antiretroviral discovered with Antonín Holý at IOCB Prague.

First once-daily single-tablet HIV regimen, built on the tenofovir family of compounds.

Modern fixed-dose HIV therapy whose backbone traces back to IOCB nucleotide chemistry.

Azacitidine — a hypomethylating agent used to treat myelodysplastic syndromes.

Decitabine — second-generation hypomethylating agent for hematologic malignancies.

Lutetium-177 radioligand therapy for targeted treatment of advanced cancers.

Sirpiglenastat — a glutamine antagonist prodrug in clinical development for solid tumors.

Long-acting oxytocin analogue used to prevent postpartum hemorrhage worldwide.

Vasopressin analogue treating diabetes insipidus, nocturnal enuresis and bleeding disorders.

Synthetic polymer-based antibody mimetics — a versatile bioconjugation platform.